FIGURE

Fig. 5

ID
ZDB-FIG-190403-9
Publication
Hsieh et al., 2018 - Global Expression Profiling Identifies a Novel Hyaluronan Synthases 2 Gene in the Pathogenesis of Lower Extremity Varicose Veins
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Fig. 5

Knockdown of hyaluronan synthases 2 gene (HAS2) in zebrafish embryos leads to dilated venous structure. Tg(fli1:egfp)xTg(gata1:dsRed) zebrafish with green fluorescence emitting vasculature are used to observe the anatomic change of vasculature. (A) Inter-segmental veins (ISVs) in the tail of a representative wild-type zebrafish (48 hpf) under fluorescence microscope (arrows); (B) Dilated ISVs in the tail of a representative HAS2-morpholino (MO) injected zebrafish (48 hpf) under fluorescence microscope (arrows); (C) The sub-intestinal vein (SIV) in the tail of a representative wild-type zebrafish (48 hpf) under fluorescence microscope (arrow); (D) The dilated SIV (arrow) with protruding branches (arrowheads) in the tail of a representative HAS2-morpholino (MO) injected zebrafish (48 hpf) under fluorescence microscope. Hpf indicates hours post-fertilization. Magnification is 400×. Scale bar = 100 ?m.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Knockdown Reagent:
Observed In:
Stage: Long-pec

Phenotype Detail
Acknowledgments
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