FIGURE

Fig. 5

ID

ZDB-FIG-190403-9

Publication

Hsieh et al., 2018 - Global Expression Profiling Identifies a Novel Hyaluronan Synthases 2 Gene in the Pathogenesis of Lower Extremity Varicose Veins

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Fig. 5

Knockdown of hyaluronan synthases 2 gene (HAS2) in zebrafish embryos leads to dilated venous structure. Tg(fli1:egfp)xTg(gata1:dsRed) zebrafish with green fluorescence emitting vasculature are used to observe the anatomic change of vasculature. (A) Inter-segmental veins (ISVs) in the tail of a representative wild-type zebrafish (48 hpf) under fluorescence microscope (arrows); (B) Dilated ISVs in the tail of a representative HAS2-morpholino (MO) injected zebrafish (48 hpf) under fluorescence microscope (arrows); (C) The sub-intestinal vein (SIV) in the tail of a representative wild-type zebrafish (48 hpf) under fluorescence microscope (arrow); (D) The dilated SIV (arrow) with protruding branches (arrowheads) in the tail of a representative HAS2-morpholino (MO) injected zebrafish (48 hpf) under fluorescence microscope. Hpf indicates hours post-fertilization. Magnification is 400×. Scale bar = 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sd2Tg; y1Tg + MO4-has2
Knockdown Reagent:	MO4-has2
Observed In:	caudal fin intersegmental vein caudal fin subintestinal vein vein
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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