ZFIN ID: ZDB-FIG-181207-70
Teng et al., 2018 - Altered bone growth dynamics prefigure craniosynostosis in a zebrafish model of Saethre-Chotzen syndrome. eLIFE   7 Full text @ Elife
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Antibody:
Fish:
Anatomical Terms:
Stage: Days 30-44
PHENOTYPE:
Fish:
Observed In:
Stage: Days 30-44

Fig. 5-S1

Accelerated bone fronts in tcf12; twist1b mutants transgenic for sp7:EGFP.

Live imaging of sp7:EGFP was performed on wild-type sibling controls (n = 11) and tcf12; twist1b mutants (n = 7) at 10 mm standard length. Dorsal views of the skull bones showed accelerated and dysmorphic bone fronts in all mutants examined. To the right, bone fronts of individual fish were traced and overlaid according to genotype. Scale bar, 250 ┬Ám.

Gene Expression Details No data available
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab1-sp7 IHC b1212Tg standard conditions Days 30-44 cranial vault osteoblast
IHC Days 30-44 frontal bone osteoblast
IHC Days 30-44 parietal bone osteoblast
IHC twist1bel570/el570 ; tcf12el548/el548 ; b1212Tg standard conditions Days 30-44 cranial vault osteoblast
IHC Days 30-44 frontal bone osteoblast
IHC Days 30-44 parietal bone osteoblast
Phenotype Details
Fish Conditions Stage Phenotype
twist1bel570/el570 ; tcf12el548/el548 ; b1212Tg standard conditions Days 30-44 frontal bone bone growth increased occurrence, abnormal
Days 30-44 frontal bone morphology, abnormal
Days 30-44 parietal bone bone growth increased occurrence, abnormal
Days 30-44 parietal bone morphology, abnormal
Acknowledgments:
ZFIN wishes to thank the journal eLIFE for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Elife