ZFIN ID: ZDB-FIG-181116-59
Haller et al., 2018 - A missense variant in SLC39A8 is associated with severe idiopathic scoliosis. Nature communications   9:4171 Full text @ Nat. Commun.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Adult

Fig. 4

Skeletal abnormalities and growth deficit in slc39a8−/− zebrafish. a Thoracic and caudal vertebral malformations causing mild spinal curvature in slc39a8−/− zebrafish (bottom) compared to WT (top) stained with alizarin red. Magnified images show vertebral fusions in KO fish. Scale bar 5 mm. b slc39a8−/− zebrafish have more spinal abnormalities than WT fish. c Reduced length of slc39a8−/− zebrafish (N = 20) compared to wild-type (N = 20) at 9 mpf ***p < 10−6, t-test. Lines are mean, first and third quartiles

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
slc39a8stl583/stl583(AB) standard conditions Adult caudal vertebra malformed, abnormal
Adult non-Weberian precaudal vertebra increased curvature, abnormal
Adult non-Weberian precaudal vertebra malformed, abnormal
Adult whole organism decreased length, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Nature communications for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Nat. Commun.