ZFIN ID: ZDB-FIG-181116-59
Haller et al., 2018 - A missense variant in SLC39A8 is associated with severe idiopathic scoliosis. Nature communications   9:4171 Full text @ Nat. Commun.
Observed In:
Stage: Adult

Fig. 4

Skeletal abnormalities and growth deficit in slc39a8−/− zebrafish. a Thoracic and caudal vertebral malformations causing mild spinal curvature in slc39a8−/− zebrafish (bottom) compared to WT (top) stained with alizarin red. Magnified images show vertebral fusions in KO fish. Scale bar 5 mm. b slc39a8−/− zebrafish have more spinal abnormalities than WT fish. c Reduced length of slc39a8−/− zebrafish (N = 20) compared to wild-type (N = 20) at 9 mpf ***p < 10−6, t-test. Lines are mean, first and third quartiles

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
slc39a8stl583/stl583(AB) standard conditions Adult caudal vertebra malformed, abnormal
Adult non-Weberian precaudal vertebra increased curvature, abnormal
Adult non-Weberian precaudal vertebra malformed, abnormal
Adult whole organism decreased length, abnormal
ZFIN wishes to thank the journal Nature communications for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Nat. Commun.