FIGURE

Fig. 4

ID

ZDB-FIG-180927-28

Publication

Xiao et al., 2018 - The roles of SMYD4 in epigenetic regulation of cardiac development in zebrafish

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Fig. 4

Phenotypical analyses of MZsmyd4^L544Efs*1 embryos.

(A) The p-H3(S10) immunofluorescence staining showed decreased cell proliferative activity in MZsmyd4^L544Efs*1 cardiomyocytes at 48 hpf. The number of p-H3 (S10) positive cells in the MZsmyd4^L544Efs*1 ventricles was significantly decreased when compared to the control group (p<0.01, **); (B) The abnormal ventricular morphology of the adult MZsmyd4^L544Efs*1 hearts compared to the morphology of control adult hearts; (C) Histological sections and H&E staining images of the adult MZsmyd4^L544Efs*1 and control hearts, demonstrating significant thickening of the compact ventricular wall. (The red arrows showed that in the similar compact zone of the ventricle). The quantitative analysis displayed that the thickness of the ventricle compact zone was significantly increased in adult MZsmyd4 ^L544Efs*1 hearts compared to Tg(cmcl2:GFP) (p<0.05, *).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	smyd4^{zf3020/zf3020}; zf2036Tg
Observed In:	cardiac muscle cell cell population proliferation compact layer of ventricle
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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