FIGURE
Fig. 6
- ID
- ZDB-FIG-180917-29
- Publication
- Svahn et al., 2018 - Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons
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Fig. 6
Fragment release from a neuron undergoing UV-induced degeneration in the absence of functional microglia. ai Cytoplasmic mTagBFP signal pre-irradiation. aii eGFP-TDP43WT distribution in the soma pre-irradiation. aiii Merged images. bi–vi mTagBFP during UV-induced degeneration. Concentrated fragments can be observed separating from the external membrane before the cytoplasm disperses. ci–vi eGFP-TDP43WT during degeneration. Concentrated fragments can be observed collecting and releasing from the membrane. The concentrated (pyknotic) nuclear core gradually fragments. Scale = 2 µm |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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Full text @ Acta Neuropathol.