ZFIN ID: ZDB-FIG-180917-24
Svahn et al., 2018 - Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons. Acta Neuropathologica   136(3):445-459 Full text @ Acta Neuropathol.
Anatomical Terms:
Stage: Protruding-mouth

Fig. 1

Fluorescent primary motor neurons in the zebrafish spinal cord at 3 dpf. a Maximum intensity projection of a z-stack of a motor neuron revealing the complete axonal arbour (yellow) projecting into and around the myotome (not shown). At the cell body the spindly dendritic arbour can also be observed. The nucleus is visualised in mCerulean3 (cyan). Traversing the image is the axon of a spinal interneuron. Scale = 10 µm. b A separate fluorescent motor neuron (bi), demonstrating the mnx1-driven membrane-bound mKO2-CAAX (yellow, bii), nuclear H2B-mCerulean3 (cyan, biii) and HsaTDP43WT-linked eGFP (green, biv). Scale = 2 µm

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
Cerulean mq14Tg ; mq13Tg control Protruding-mouth primary motor neuron nucleus IFL
EGFP mq14Tg ; mq13Tg control Protruding-mouth primary motor neuron nucleus IFL
mKOFP2 mq14Tg ; mq13Tg control Protruding-mouth primary motor neuron axon IFL
Protruding-mouth primary motor neuron dendrite IFL
Protruding-mouth primary motor neuron membrane IFL
Antibody Labeling Details No data available
Phenotype Details No data available
ZFIN wishes to thank the journal Acta Neuropathologica for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Acta Neuropathol.