FIGURE

Fig. 5

ID

ZDB-FIG-180820-13

Publication

Madelaine et al., 2018 - A screen for deeply conserved non-coding GWAS SNPs uncovers a MIR-9-2 functional mutation associated to retinal vasculature defects in human

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Fig. 5

CNE1 regulates MIR-9-2/miR-9-5 expression. (A) Schematic of the zebrafish genomic region containing pre-miR-9-5 and CNE1. pre-miR-9-5 and CNE1 are intronic in si:ch211-202e12.3, a long non-coding RNA. Three transcription starts (TSS, green arrows), host and intronic, are used for pri-miR-9-5 transcription (46). (B–F) Whole-mount ISH against host and intronic pri-miR-9-5s (probe 1 and 2, respectively), pre-miR-9-5 (probe 3), tmem161b or mef2c in control and ΔCNE1 larvae at 72 hpf. The expression of pri- and pre-miR-9-5, but not tmem161b and mef2c, is reduced in the brain of homozygous ΔCNE1 mutants. Dorsal view of the brain with anterior up. Scale bars: 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nucleic Acids Res.