FIGURE

Fig. 1

ID

ZDB-FIG-180713-19

Publication

LeCorgne et al., 2018 - Differential Toxicity of mDia Formin-Directed Functional Agonists and Antagonists in Developing Zebrafish

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Fig. 1

Formin antagonism induces tail curving and peripheral tail cell death in developing zebrafish embryos. (A) Representative 2x images at 21 hpt untreated (None) and in 10 μM SMIFH2 (arrow indicates peripheral tail cell death). Scale bar = 2,000 μm. (B–D) Tail degradation was scored for embryos in each untreated, vehicle, and SMIFH2 (B), IMM (C), and PEG-DAD (D) drug conditions. (E-G). Tail curvature was scored for embryos in each untreated, vehicle, and SMIFH2 (E), IMM (F), and PEG-DAD (G) drug condition. The screens were performed in triplicate, five embryos/well and the experiment was repeated three times. p-Value is relative to untreated condition. Error bars indicate SE.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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