FIGURE

Fig. 6

ID

ZDB-FIG-180706-42

Publication

Liu et al., 2018 - CRISPR/Cas9-induced shank3b mutant zebrafish display autism-like behaviors.

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Fig. 6

shank3b deficiency altered the neurodevelopment in larvae. a–c Reduced RFP staining in shank3b^−/− larvae compared to shank3b^+/+ larvae (1 dpf, 2 dpf, and 3 dpf) using Huc: RFP transgene line zebrafish. The difference is the most prominent at 1 dpf. Scale bar, 100 μm. a’–c’ RT-qPCR results of RFP expressions from (a–c) larvae. N = 8 for each group. Data are presented as mean ± SEM; *p < 0.05, ****p < 0.0001

Expression Data

Gene:	RFP
Fish:	fdu101Tg shank3b^{fdu201/fdu201}; fdu101Tg
Anatomical Term:	central nervous system
Stage Range:	Prim-5 to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	shank3b^{fdu201/fdu201}; fdu101Tg
Observed In:	central nervous system neuron development
Stage Range:	Prim-5 to Long-pec

Phenotype Detail

Acknowledgments

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