FIGURE

Fig. 2

ID

ZDB-FIG-180626-12

Publication

Du et al., 2018 - Transgenic Expression of A Venous Malformation Related Mutation, TIE2-R849W, Significantly Induces Multiple Malformations of Zebrafish.

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Fig. 2

Obvious eye defects of zebrafish caused by humanized TIE2-R849W. (A) At 52 hpf, compared to normal embryogenesis of eyes in the control group, from the angle of dorsal view and ventral view, there exist apparently unilateral or bilateral eyelessness, reduction of size in one side and eye-fusion at dorsal position (impaired eyes are indicated by blue arrow). (B) Quantification of eye defects in control and TIE2-R849W group at 52 hpf. (C) Histological research (HE) on reduced size eye (7 dpf) indicates loss of lens (indicated by green asterisk), abnormal plexiform layer (indicated by yellow asterisk), and still-recognizable separated layer structure (showed by partial enlargement). (HE, hematoxylin and eosin staining; scale bars are 100 μm for C.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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