FIGURE

Fig. 1

ID

ZDB-FIG-180620-28

Publication

Zhou et al., 2018 - MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

miR-223-Deficient Embryos Display Augmented Neutrophil Response to Tissue Injury

(A) Sequences of pre-mir-223 in WT and miR-223 mutant embryos. Mutated nucleotides are labeled in red.

(B) The hairpin structures of miR-223 in WT and mutant embryos predicted by Centroidfold.

(D and E) Representative images (D) and quantification (E) of total neutrophil numbers in WT and miR-223^−/− embryos.

(F and G) Representative images (F) and quantification (G) of neutrophil recruitment to tail transection sites in WT and miR-223^−/− embryos at 1 hpw and 6 hpw. The number of neutrophils in the boxed region were quantified. Scale bars, 100 μm.

Data are representative of three independent experiments (E and G) or are pooled from three independent experiments (C). Mean ± SD. ^∗∗∗p < 0.001 and ^∗∗∗∗p < 0.0001, unpaired Student’s t test. See also Figures S1 and S2.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mir223^pu18/pu18
Condition:	transection: caudal fin
Observed In:	caudal fin neutrophil neutrophil neutrophil chemotaxis
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Rep.