FIGURE

Fig. 6

ID

ZDB-FIG-180619-4

Publication

Mercer et al., 2018 - Hspb7 is a Cardioprotective Chaperone Facilitating Sarcomeric Proteostasis

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Fig. 6

Evidence of abnormalities in hspb7^WC3/WC3 adult hearts by TEM. Shown are representative transmission electron microscope images of 18 month (A) wildtype and (B) hspb7^WC3/WC3 mutant hearts. Wildtype hearts exhibit repeated, regular sarcomeric striations with organized mitochondria. The hspb7 mutant heart tissue shows defects representing breakdown of sarcomeric organization (myofibril packing defects, white arrows). (C and D) Shown are two representative images of hspb7 mutant hearts that also exhibit increased number of autophagosomes (yellow arrowheads). (E) Graphs show quantification of relative occurrence rate (averaged number of defects over the total imaged area) of myofibril packing defects and autophagosomes in the wildtype and hspb7 mutant hearts (n = 3 independent hearts for each). The difference in the rate of each defect was determined using an Exact Poisson test in R.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hspb7^wcm3/wcm3
Observed In:	heart autophagosome heart cardiac myofibril sarcomere organization
Stage:	Adult

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 435(1), Mercer, E.J., Lin, Y.F., Cohen-Gould, L., Evans, T., Hspb7 is a Cardioprotective Chaperone Facilitating Sarcomeric Proteostasis, 41-55, Copyright (2018) with permission from Elsevier. Full text @ Dev. Biol.