FIGURE

Fig. 2

ID

ZDB-FIG-180426-6

Publication

McGurk et al., 2017 - In vivo zebrafish morphogenesis shows Cyp26b1 promotes tendon condensation and musculoskeletal patterning in the embryonic jaw

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Fig. 2

The b1024 lesion is a nonsense mutation in cyp26b1 that causes skeletal defects. (A-B) Wild-type head skeleton stained with Alcian Blue and Alizarin Red dyes. (C) In b1024 mutants the ethmoid plate (brackets in A,C) and parasphenoid bone are narrow and the parachordal (arrows in A,C), basicapsular commissure (arrowheads in A,C), and lateral commissure (asterisks in A,C) cartilages of the posterior neurocranium are hypoplastic. (D) The midline symphysis of Meckel’s (red arrowheads and red insets in B,D) and ceratohyal (black arrowheads and black insets in B,D) cartilages are absent in b1024 homozygotes, fusing the left and right cartilage elements, and the basihyal cartilage (arrows in B,D) is hypoplastic. (E-F) A single base substitution in cyp26b1 (arrowhead) results in an in-frame stop codon (box). (G) b1024 causes a later truncation of cyp26b1 than previously characterized alleles, but still eliminates essential components of the cytochrome P450 enzyme domain encoded in exon 6. All images ventral view, anterior to the left. Scale bars = 50 μm

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cyp26b1^b1024/b1024
Observed In:	basihyal cartilage anterior region ceratohyal cartilage medial region embryonic neurocranium morphogenesis embryonic viscerocranium morphogenesis ethmoid cartilage Meckel's cartilage medial region parachordal cartilage parasphenoid
Stage:	Day 4

Phenotype Detail

Acknowledgments

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