FIGURE

Fig. S11

ID

ZDB-FIG-180208-28

Publication

Pérez-López et al., 2017 - Gold-Triggered Uncaging Chemistry in Living Systems

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Fig. S11

Time-course analysis and representative images of the bioorthogonal gold-mediated release of green fluorescent rhodamine 110 from precursor 1 in the brain of a zebrafish. Study of fluorescence intensity between the persistent (group A, in black) vs the intermittent (group B, in grey) treatment at 3 dpt shows statistical significance. This study further corroborated previous observations in cancer cell culture. Persistent treatment with reagent 1 (group A), enabled the local generation of dye 2 in the brain and the sustenance of high levels of fluorescence over the life of the study. In contrast, after interrupting the treatment for 2 d (group B), local levels of fluorescence decreased, likely due to the metabolization / elimination of compound 2. 24 h after resuming the treatment (3 to 4 dpt), high intensity of local fluorescence in the area of the [Au]-resin was restored. Importantly, treatment with reagent 1 in the absence of [Au]- resin did not change fluorescence levels in the brain over the background control.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Angew. Chem. Int. Ed. Engl.