ZFIN ID: ZDB-PUB-170713-4
Gold-Triggered Uncaging Chemistry in Living Systems
Pérez-López, A.M., Rubio-Ruiz, B., Sebastián, V., Hamilton, L., Adam, C., Bray, T.L., Irusta, S., Brennan, P.M., Lloyd-Jones, G., Sieger, D., Santamaría, J., Unciti-Broceta, A.
Date: 2017
Source: Angewandte Chemie (International ed. in English)   56(41): 12548-12552 (Journal)
Registered Authors: Sieger, Dirk
Keywords: Bioorthogonal, Prodrugs, fluorescent probes, gold, heterogeneous catalysis
MeSH Terms:
  • A549 Cells
  • Animals
  • Antineoplastic Agents/administration & dosage*
  • Antineoplastic Agents/pharmacokinetics
  • Brain/metabolism
  • Catalysis
  • Delayed-Action Preparations/chemistry*
  • Fluorescent Dyes/administration & dosage*
  • Fluorescent Dyes/pharmacokinetics
  • Gold/chemistry*
  • Humans
  • Zebrafish
PubMed: 28699691 Full text @ Angew. Chem. Int. Ed. Engl.
Recent advances in bioorthogonal catalysis are increasing our capacity to manipulate the fate of molecules in complex biological systems. Herein we report a novel bioorthogonal uncaging strategy that is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally-diverse range of therapeutics in cancer cell culture. Furthermore, this solid supported catalytic system enabled -for the first time- the locally-controlled release of a fluorescent dye in the brain of a zebrafish, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs.