FIGURE

Fig. 3

ID

ZDB-FIG-171229-39

Publication

Bao et al., 2017 - Inhibition of H3K27me3 Histone Demethylase Activity Prevents the Proliferative Regeneration of Zebrafish Lateral Line Neuromasts

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Fig. 3

GSK-J4 induced apoptosis in the regenerating neuromasts. (A,B) Cleaved caspase-3 staining in the neuromasts from a DMSO-treated control larva (A) and a GSK-J4-treated larva (B) at 48 h after neomycin damage. Scale bar = 10 μm. (C) Quantitative analysis of the number of cleaved caspase-3-labeled cells in DMSO-treated control and GSK-J4-treated larvae. n = 24 neuromasts (12 larvae) per group. **p < 0.001 (unpaired t-test, two-tailed, t = 3.368, df = 44, p = 0.0016). (D) Cleaved-caspase-3-specific western blot analysis of whole larvae treated with either DMSO (neo Con; n = 6 larvae) or 10 μM GSK-J4 (neo GSK-J4; n = 6 larvae) for 48 h. The relative expressions of cleaved-caspase-3/β-actin were calculated. **p < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.