FIGURE

Fig. 5

ID

ZDB-FIG-171121-13

Publication

Ashikawa et al., 2016 - Activation of Sterol Regulatory Element Binding Factors by Fenofibrate and Gemfibrozil Stimulates Myelination in Zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

Fenofibrate and gemfibrozil increase mbp promoter-driven fluorescent reporter expression through activation of SREBFs. (A) Representative images from in vivo analysis of Tg (mbp: mCitrine, eno2: Cerulean) zebrafish incubated with or without the indicated concentrations of fenofibrate, gemfibrozil, and fatostatin. (B,C) Quantification of mCitrine fluorescence intensity within the area of Cerulean fluorescence. (B) Zebrafish were untreated (n = 28) or treated with fenofibrate (n = 27), fatostatin (n = 20), or fenofibrate and fatostatin (n = 5). ^∗p < 0.05 compared with control. (C) Zebrafish were untreated (n = 7) or treated with gemfibrozil (n = 7), fatostatin (n = 8), or gemfibrozil and fatostatin (n = 8). ^∗p < 0.05 compared with control.

Expression Data

Gene:	Citrine
Fish:	slc45a2^b4/b4; zf1046Tg; zf720Tg
Conditions:	chemical treatment by environment: fenofibrate chemical treatment by environment: gemfibrozil
Anatomical Term:	oligodendrocyte
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	slc45a2^b4/b4; zf1046Tg; zf720Tg
Conditions:	chemical treatment by environment: fenofibrate chemical treatment by environment: gemfibrozil
Observed In:	myelination oligodendrocyte
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Pharmacol