FIGURE

Fig. 4

ID

ZDB-FIG-171121-12

Publication

Ashikawa et al., 2016 - Activation of Sterol Regulatory Element Binding Factors by Fenofibrate and Gemfibrozil Stimulates Myelination in Zebrafish

Other Figures

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Fig. 4

Effects of thyroid hormone modulators on mbp promoter-driven fluorescence in zebrafish. (A) Representative images from in vivo analysis of Tg (mbp: mCitrine, eno2: Cerulean) zebrafish incubated with or without the indicated concentrations of methimazole (MMI), propylthiouracil (PTU), or thyroxine (T4). (B) Quantification of mCitrine fluorescence intensity within the area of Cerulean fluorescence. (Top) Zebrafish were untreated (n = 40) or treated with MMI (n = 16 for 0.5 mM, n = 26 for 1 mM, n = 27 for 2 mM). (Middle) Zebrafish were untreated (n = 11) or treated with PTU (n = 5 for 1 mM, n = 10 for 2 mM, n = 3 for 3 mM). (Bottom) Zebrafish were untreated (n = 20) or treated with T4 (n = 6 for 10 nM, n = 5 for 20 nM, n = 9 for 30 nM). ^∗∗p < 0.01, ^∗∗∗∗p < 0.0001 compared with control.

Expression Data

Genes:	Cerulean Citrine
Fish:	slc45a2^b4/b4; zf1046Tg; zf720Tg
Conditions:	chemical treatment by environment: methimazole chemical treatment by environment: 6-propyl-2-thiouracil chemical treatment by environment: thyroxine
Anatomical Terms:	neuron oligodendrocyte
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	slc45a2^b4/b4; zf1046Tg; zf720Tg
Conditions:	chemical treatment by environment: methimazole chemical treatment by environment: 6-propyl-2-thiouracil chemical treatment by environment: thyroxine
Observed In:	myelination oligodendrocyte
Stage:	Day 5

Phenotype Detail

Acknowledgments

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