|ZFIN ID: ZDB-FIG-171011-10|
ccdc41 is expressed in ciliated tissues and its depletion induces olfactory ciliogenesis defects in zebrafish. (A) Alignment of human and zebrafish CCDC41 protein sequences by using the ClustalX program. (B) ccdc41 whole-mount in situ hybridization shows that ccdc41 mRNA is expressed in olfactory placodes (arrow), pronephric duct (arrowhead), and tail myotomes at 24 h postfertilization. (Inset) Frontal view of the head shows ccdc41 expression in bilateral olfactory placodes. (C) Anti–acetylated-tubulin (Act-Tub) antibody staining of the zebrafish nasal pit at 5 d postfertilization. MO, morpholino.
|cep83||WT||standard conditions||Prim-5||olfactory placode||ISH|
|WT + MO1-cep83||standard conditions||Day 5||cilium assembly disrupted, abnormal|
|Day 5||olfactory pit cilium decreased amount, abnormal|
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