Gene

cep83

ID

ZDB-GENE-110321-1

Name

centrosomal protein 83

Symbol

cep83 Nomenclature History

Previous Names

ccdc41

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Involved in cilium assembly. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of ciliary transition fiber. Predicted to be active in Golgi apparatus; centriole; and centrosome. Is expressed in olfactory placode; post-vent region; and pronephric duct. Human ortholog(s) of this gene implicated in nephronophthisis 18. Orthologous to human CEP83 (centrosomal protein 83).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Joo et al., 2013

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Joo et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa40283	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

1 - 1 of 1

Show

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Citations
MO1-cep83	N/A	Joo et al., 2013

1 - 1 of 1

Show

Human Disease

Associated With cep83 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nephronophthisis 18	Alliance	Nephronophthisis 18	615862

1 - 1 of 1

Associated With cep83 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR052116	Centrosome and Cilium Assembly Protein

1 - 1 of 1

Domain Details Per Protein

Protein	Length	Centrosome and Cilium Assembly Protein
UniProtKB:A0A0R4IVY9 InterPro	725
UniProtKB:A0A8M3ARI8 InterPro	722

1 - 2 of 2

Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 4

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cep83-201 (1) Ensembl	Ensembl	2,106 nt	Select Tool ZFIN BLAST
mRNA	cep83-203 (1) Ensembl	Ensembl	3,874 nt	Select Tool ZFIN BLAST
ncRNA	cep83-002 (1) Ensembl	Ensembl	651 nt	Select Tool ZFIN BLAST

1 - 3 of 3

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	Fosmid	CH1073-175N15	CU693442	ZFIN Curated Data

1 - 1 of 1

Show

Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001353931 (1)	3167 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CABZ01023256 (1)	45989 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A0R4IVY9 (1)	725 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	CEP83	12	Ensembl:ENSG00000173588 Gene:51134 OMIM:615847 HGNC:17966	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Cep83	10	Ensembl:ENSMUSG00000020024 MGI:1924298 Gene:77048	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)

Citations

Include unpublished citations

Joo, K., Kim, C.G., Lee, M.S., Moon, H.Y., Lee, S.H., Kim, M.J., Kweon, H.S., Park, W.Y., Kim, C.H., Gleeson, J.G., Kim, J. (2013) CCDC41 is required for ciliary vesicle docking to the mother centriole.. Proceedings of the National Academy of Sciences of the United States of America. 110(15):5987-92

1 - 1 of 1

Show