FIGURE

Fig. 1

ID

ZDB-FIG-171002-1

Publication

Shimizu et al., 2017 - The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes

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Fig. 1

Disorganized myofibril structure in tre/ncx1h cardiomyocytes.

Wild type (WT) and tre/ncx1h (tre) mutant hearts at 30, 48 and 72 hpf. (A) Zebrafish hearts stained for α-actinin to visualize Z-lines. At 30 hpf, periodic α-actitin staining was observed in wild type and tre hearts (arrowheads). By 48 hpf, sarcomeres are disassembled in tre hearts. Scale bar, 10 μm. (B) The cell shape of cardiomyocytes was visualized by Zn8 staining. Scale bar, 10 μm. (C) Embryonic fish hearts were visualized by GFP expression in the myl7:EGFP transgenic background. Note that tre hearts become dysmorphic after two days of development. Scale bar, 50 μm.

Expression Data

Gene:	EGFP
Antibody:	zn-8
Fish:	WT slc8a1a^{tc318d/tc318d} twu34Tg slc8a1a^{tc318d/tc318d}; twu34Tg
Anatomical Terms:	cardiac muscle cell heart heart tube
Stage Range:	Prim-15 to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	slc8a1a^{tc318d/tc318d} slc8a1a^{tc318d/tc318d}; twu34Tg
Observed In:	atrium cardiac muscle cell cardiac muscle cell cardiac myofibril cardiac muscle cell sarcomere cardiac ventricle
Stage Range:	Prim-15 to Protruding-mouth

Phenotype Detail

Acknowledgments

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