FIGURE

Fig. 3

ID

ZDB-FIG-170911-7

Publication

Santos-Ledo et al., 2017 - Kinesin-1 promotes chondrocyte maintenance during skeletal morphogenesis

Other Figures

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Fig. 3

mpeded mineralization in kif5Blof.

Confocal projections of images of live embryos at 6 dpf (A, D) and 11 dpf (B, C, E, F). GFP stained chondrocytes and Alizarin Red stained mineralized matrix. Intramembranous bones (MD, P and B) show mineralization but were shorter at 6 dpf (A, D). BC, the only endochondral bone at this stage, mineralization was deficient but evidence of mineralization is detectable (insets in D). At 11 dpf membranous and perichondral ossification had progressed in Wt (B) and vertebraes were apparent (C). In kif5Blof membranous ossification had also progressed (E) and vertebraes were mineralized (F). However, perichondral ossification was defective as indicated by the absence of BC (E). B: branchiostegal; BC: bone collars; P: entopterygoid; D: dentary.

Expression Data

Gene:	EGFP
Fish:	ba2Tg kif5ba^ae12/ae12; kif5bb^ae24/ae24; ba2Tg
Anatomical Term:	chondrocyte
Stage Range:	Day 6 to Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kif5ba^ae12/ae12; kif5bb^ae24/ae24; ba2Tg
Observed In:	branchiostegal ray dentary endochondral bone bone mineralization entopterygoid perichondral bone bone mineralization
Stage Range:	Day 6 to Days 7-13

Phenotype Detail

Acknowledgments

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