ZFIN ID: ZDB-FIG-170908-37
Mathews et al., 2016 - Cholesterol Biosynthesis Supports Myelin Gene Expression and Axon Ensheathment through Modulation of P13K/Akt/mTor Signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience   36:7628-39 Full text @ J. Neurosci.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Antibodies:
Fish:
Conditions:
Anatomical Term:
Stage: Day 4
PHENOTYPE:
Fish:
Conditions:
Observed In:
Stage: Day 4

Fig. 1 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
EGFP hmgcs1vu57/vu57; vu12Tg standard conditions Day 4 spinal cord oligodendrocyte IHC
hmgcs1vu57/vu57; vu12Tg chemical treatment by injection: cholesterol Day 4 spinal cord oligodendrocyte IHC
vu12Tg standard conditions Day 4 spinal cord oligodendrocyte IHC
vu12Tg chemical treatment by environment: Ro 48-8071 Day 4 spinal cord oligodendrocyte IHC
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab1-rps6 IHC hmgcs1vu57/vu57; vu12Tg standard conditions Day 4 spinal cord oligodendrocyte
IHC hmgcs1vu57/vu57; vu12Tg chemical treatment by injection: cholesterol Day 4 spinal cord oligodendrocyte
IHC vu12Tg standard conditions Day 4 spinal cord oligodendrocyte
IHC vu12Tg chemical treatment by environment: Ro 48-8071 Day 4 spinal cord oligodendrocyte
Ab20-mapk IHC hmgcs1vu57/vu57; vu12Tg standard conditions Day 4 spinal cord oligodendrocyte
IHC hmgcs1vu57/vu57; vu12Tg chemical treatment by injection: cholesterol Day 4 spinal cord oligodendrocyte
IHC vu12Tg standard conditions Day 4 spinal cord oligodendrocyte
IHC vu12Tg chemical treatment by environment: Ro 48-8071 Day 4 spinal cord oligodendrocyte
Phenotype Details
Fish Conditions Stage Phenotype
hmgcs1vu57/vu57; vu12Tg standard conditions Day 4 oligodendrocyte MAPK cascade decreased occurrence, abnormal
Day 4 oligodendrocyte TOR signaling decreased occurrence, abnormal
Day 4 spinal cord oligodendrocyte ab1-rps6 labeling decreased amount, abnormal
Day 4 spinal cord oligodendrocyte ab20-mapk labeling decreased amount, abnormal
hmgcs1vu57/vu57; vu12Tg chemical treatment by injection: cholesterol Day 4 oligodendrocyte MAPK cascade decreased occurrence, abnormal
Day 4 oligodendrocyte TOR signaling occurrence, ameliorated
Day 4 spinal cord oligodendrocyte ab1-rps6 labeling amount, ameliorated
Day 4 spinal cord oligodendrocyte ab20-mapk labeling decreased amount, abnormal
vu12Tg chemical treatment by environment: Ro 48-8071 Day 4 oligodendrocyte MAPK cascade decreased occurrence, abnormal
Day 4 oligodendrocyte TOR signaling decreased occurrence, abnormal
Day 4 spinal cord oligodendrocyte ab1-rps6 labeling decreased amount, abnormal
Day 4 spinal cord oligodendrocyte ab20-mapk labeling decreased amount, abnormal
Full text @ J. Neurosci.