FIGURE

Fig. S4

ID

ZDB-FIG-170908-2

Publication

Fukuda et al., 2017 - Proteolysis regulates cardiomyocyte maturation and tissue integration

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Fig. S4

asb2b mutant cardiomyocytes in WT hearts exhibit disorganized myofilaments. (a) Quantification of fractional shortening (FS) in ventricles and atria in 50 hpf chimeric hearts, and aortic blood flow velocity. WT or asb2b mutant cells were transplanted into WT host embryos. No significant differences in FS or blood flow velocity were observed (n=3 to 7 fish). (b) 3D images of 120 hpf chimeric ventricles. Tg(myl7:LIFEACT-GFP) WT or asb2b mutant donor cells were transplanted into Tg(myl7:LIFEACT-tdTomato) WT host embryos. WT donor-derived cardiomyocytes exhibit mature sarcomeres in trabecular cardiomyocytes, while asb2b mutant-derived cardiomyocytes exhibit disorganized sarcomeres. (c) A 50 hpf TgBAC(asb2b:GFP-asb2b) heart stained with DAPI (blue). Scale bars, 20 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.