FIGURE

Fig. 2

ID

ZDB-FIG-170719-10

Publication

García-Valtanen et al., 2017 - Zebra Fish Lacking Adaptive Immunity Acquire an Antiviral Alert State Characterized by Upregulated Gene Expression of Apoptosis, Multigene Families, and Interferon-Related Genes

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Fig. 2

Naïve adult rag1^−/− zebra fish are more resistant to lethal spring viremia carp virus (SVCV) infection than rag1^+/+ zebra fish. (A) Kaplan–Meier survival curves of naïve rag1^−/− (n = 84) and rag⁺^/+ (n = 100) adult zebra fish after exposure to a lethal dose of 10⁴ pfu/ml of SVCV under the same challenge conditions as in panel (A). *Statistically significant differences between survival curves between rag1^−/− and rag⁺^/+ as determined by the Gehan–Breslow–Wilcoxon test with p < 0.05 (n = 2). Solid lines, rag1^−/− zebra fish larvae. Dashed lines, rag⁺^/+ zebra fish larvae. (B) SVCV titers from pooled whole zebra fish (n = 4 zebra fish per genotype) 3 days after SVCV infection as determined by plaque forming unit (pfu) assays.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT rag1^{t26683/t26683}
Condition:	viral treatment by exposure to environment: Sprivivirus cyprinus
Observed In:	whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

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