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General Information
ZIRC
ZFIN ID: ZDB-FIG-170713-5
Li et al., 2014 - Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy. Cell Research   24:977-93 Full text @ Cell Res.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Antibodies:
Fish:
Knockdown Reagents:
Anatomical Terms:
Stage: Long-pec
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage Range: Long-pec to Day 5

Fig. 4 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
EGFP twu34Tg control Long-pec heart IFL
twu34Tg + MO1-tomm70a standard conditions Long-pec heart IFL
twu34Tg + MO2-tomm70a standard conditions Long-pec heart IFL
tomm70a WT + MO1-tomm70a standard conditions Long-pec whole organism WB
WT + MO2-tomm70a standard conditions Long-pec whole organism WB
Long-pec whole organism RTPCR
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab1-tomm70 WB WT standard conditions Long-pec whole organism
WB WT + MO1-tomm70a standard conditions Long-pec whole organism
WB WT + MO2-tomm70a standard conditions Long-pec whole organism
zn-8 IHC twu34Tg control Long-pec heart
IHC twu34Tg + MO1-tomm70a standard conditions Long-pec heart
IHC twu34Tg + MO2-tomm70a standard conditions Long-pec heart
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-tomm70a standard conditions Long-pec cardiac muscle cell increased size, abnormal
Long-pec heart contraction decreased process quality, abnormal
Long-pec whole organism tomm70a expression decreased amount, abnormal
Long-pec whole organism Ab1-tomm70 labeling decreased amount, abnormal
Day 5 cardiac ventricle constricted, abnormal
Day 5 heart hypertrophic, abnormal
WT + MO2-tomm70a standard conditions Long-pec cardiac muscle cell increased size, abnormal
Long-pec heart contraction decreased process quality, abnormal
Long-pec whole organism Ab1-tomm70 labeling decreased amount, abnormal
Long-pec whole organism tomm70a expression decreased amount, abnormal
Full text @ Cell Res.