FIGURE

Fig. S1

ID

ZDB-FIG-170706-9

Publication

Wager et al., 2016 - Neurodegeneration and Epilepsy in a Zebrafish Model of CLN3 Disease (Batten Disease)

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Fig. S1

Abnormal morphology was observed using two different cln3 morpholinos at 4 dpf.

(A, A') WT. (B, B') 1.6 ng cln3 ATG MO. (C, C') 12 ng cln3 SPL MO. Morphant larvae (B, B', C, C') showed small retinas, small brain, pericardial oedema, a large yolk sac and abnormal tail curvature (dashed arrows) compared to WT (A, A'). Abbreviations: r, retina; ps, pericardial sac; y, yolk; t, tail; fb, forebrain; mb, midbrain; hb, hindbrain. Lateral views. Anterior to left. Dorsal up. Scale bars: A-C 250 μm; A'-C' 125 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TL + MO2-cln3
Knockdown Reagent:	MO2-cln3
Observed In:	brain pericardium post-vent region retina yolk
Stage:	Day 4

Phenotype Detail

Acknowledgments

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