FIGURE

Fig. 1

ID

ZDB-FIG-170505-21

Publication

Torraca et al., 2017 - The chemokine receptor CXCR4 promotes granuloma formation by sustaining a mycobacteria-induced angiogenesis programme

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Fig. 1

Trunk granuloma formation and induction of angiogenesis by M. marinum.

(A,B) Schematic representation of injection location and of granuloma expansion in zebrafish embryos/larvae upon injection of Mm into the trunk. (C–E) Longitudinal imaging of vascular and bacterial growth during development of a trunk granuloma in the Tg(kdrl:eGFP) line at 3, 4 and 5 dpi. (F–K) Formation of trunk granulomas and their vascularisation in a cxcr4b^+/+ and cxcr4b^−/− larva at 5 dpi. White arrows indicate sites of abnormal vascularisation associated to bacterial growth, notably largely initiated in the wt but rare in the mutant. See also Fig. 2 for quantification. Scale bars: 100 μm.

Expression Data

Gene:	EGFP
Fish:	s843Tg cxcr4b^{t26035/t26035}; s843Tg
Condition:	bacterial treatment by injection: Mycobacterium marinum M
Anatomical Term:	trunk vasculature
Stage Range:	Day 5 to Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s843Tg cxcr4b^{t26035/t26035}; s843Tg
Condition:	bacterial treatment by injection: Mycobacterium marinum M
Observed In:	granuloma formation trunk vasculature trunk vasculature response to bacterium
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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