FIGURE

Fig. S2

ID

ZDB-FIG-170407-3

Publication

Zelina et al., 2014 - Signaling switch of the axon guidance receptor Robo3 during vertebrate evolution

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Fig. S2

Slit2 binding on mutant Robo1 and Robo3 receptors from various vertebrate species.

(A-D), hSlit2-D2-AP binds to COS cells expressing rRobo1^K90R, rRobo1^N88P but not mRobo3^P84N or hRobo3. (E, F) chicken Slit2-D2-AP binds to COS cells expressing cRobo3A.1. (G, H) xSlit2-D2-AP binds to Xenopus Robo3^N85P but does not bind to Robo3^L127P. (I-L) zebrafish Slit2-D2-AP binds to COS cells expressing zRobo3A.1^K85R but not zRobo3A.1^N83P or zRobo3A.1^N83P/K85R. (M) Scatchard analysis of hSlit2-D2-AP binding affinity to wild type and mutated Robo1 and Robo3 receptors. The data shown are representative of at least 3 independent experiments.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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