FIGURE

Fig. S3

ID

ZDB-FIG-170316-2

Publication

Caputo et al., 2015 - The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors

Other Figures

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Fig. S3

Cardiac morphogenesis defects in zebrafish embryos overexpressing DN-Ldb1. (A) Confocal images of control and FLAG-HA-DN-Ldb1 mRNA injected zebrafish embryos, stained with anti-FLAG antibody at 20 somites. (B) Control or DNLdb1 mRNA injected Tg(myl7:EGFP-HsHRAS)^s883 embryos at 48 hpf. Lateral view, anterior to the left. (C-D) Percentage of embryos with cardiac arrhythmia (C) and analysis of the number of heart beats per minute (D) measured at 24, 48 and 72 hpf in control and DN-Ldb1 overexpressing zebrafish embryos. (E) Confocal images of control, DN-Ldb1 overexpressing and Isl1 mutant Tg(myl7:EGFP-HsHRAS)^s883 hearts, showing shortening of the atrium (dotted lines) in DN-Ldb1 overexpressing and isl1 mutant embryos.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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