FIGURE

Fig. 3

ID

ZDB-FIG-170202-22

Publication

Xie et al., 2016 - Suppression of breast cancer metastasis through the inactivation of ADP-ribosylation factor 1

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Fig. 3

Knockdown of ARF1 leads to reduced cell invasion and metastasis in breast cancer. (A) The effect of shRNA-mediated ARF1 knockdown on MDA-MB-231 cells. (B) The effect of ARF1 depletion on cell invasion. (C, D, E, F) The effect of ARF1 depletion by shRNA on pulmonary metastases in the orthotopic mice model of breast cancer. (C, D) Quantitative data of lung weigh and gross surface pulmonary metastases. (E) Representative H&E stained lung sections from tumor-bearing mice. Six weeks after injection with MDA-MB-231 cells, the lungs from the NSG mice sacrificed were excised for pathological and histological analysis. Black arrows indicate representative metastatic foci. (F) The effect of ARF1 depletion by shRNA on metastatic dissemination in zebrafish. White arrows indicate disseminated MDA-MB-231 cells in the fish body. Quantitative data are shown in right panel. **p < 0.01.

Expression Data

Gene:	EGFP
Fish:	s844Tg
Condition:	cancer xenotransplantation
Anatomical Term:	vasculature
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Oncotarget