FIGURE

Fig. 3

ID

ZDB-FIG-161206-19

Publication

Zada et al., 2016 - Pharmacological and BBB-targeted genetic therapies for thyroid hormone-dependent hypomyelination

Other Figures

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Fig. 3

Increased number of Schwann cells in mct8^−/− larvae during development. (A) Lateral view of a motor neuron in 10-dpf live tg(mbp:EGFP)/tg(huc:GAL4 x uas:tagRFP) larvae shows Schwann cell (green) ensheathment of motor neuron axons (red). (B) Representative lateral-view images of Schwann cell ensheathment of motor neuron axons in the SC of 10-dpf mct8^+/+ and mct8^−/− larvae. (C) Number of Schwann cells that myelinate the axons of the motor neurons of 4 (mct8^+/+: n=9, mct8^−/−: n=9)- and 10 (mct8^+/+: n=26, mct8^−/−: n=22)-dpf larvae. (D) Number of Schwann cells that myelinate the axons of the motor neurons of untreated and T3-treated mct8^+/+ 10-dpf larvae (untreated: n=26, T3-treated: n=19). Values are represented as means±s.e.m. Statistical significance was determined by Student's t-test: two samples assuming unequal variance (*P<0.05, ***P<0.001). Scale bars: 10 µm.

Expression Data

Genes:	EGFP TagRFP
Fish:	ck1Tg biu9Tg; ck1Tg; mde4Tg slc16a2^biu4/biu4; ck1Tg
Anatomical Terms:	motor neuron axon myelinating Schwann cell
Stage:	Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT slc16a2^biu4/biu4; ck1Tg
Condition:	chemical treatment by environment: 3,3',5-triiodo-L-thyronine
Observed In:	myelinating Schwann cell
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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