FIGURE

Fig. S3

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ZDB-FIG-161205-10

Publication

Cayuso et al., 2016 - EphrinB1/EphB3b Coordinate Bidirectional Epithelial-Mesenchymal Interactions Controlling Liver Morphogenesis and Laterality

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Fig. S3

Altering EphrinB1 and EphB3b levels leads to defects in lamellipodia orientation and hepatoblast positioning. Related to Figure 6.

(A-B”) Conditional expression of UAS:ephrinB1 causes a posterior accumulation of hepatoblasts and morphological defects of the liver domain (B-B''). (C) Hepatoblast lamellipodia are oriented with respect to the anteroposterior axis. Expression of EphrinB1 and EphrinB1^6F randomises lamellipodia orientation in comparison to control and MO-ephrinB1 embryos, and similar to compromised EphB3b function (see Figure 6H).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Cell, 39, Cayuso, J., Dzementsei, A., Fischer, J.C., Karemore, G., Caviglia, S., Bartholdson, J., Wright, G.J., Ober, E.A., EphrinB1/EphB3b Coordinate Bidirectional Epithelial-Mesenchymal Interactions Controlling Liver Morphogenesis and Laterality, 316-328, Copyright (2016) with permission from Elsevier. Full text @ Dev. Cell