FIGURE

Fig. 4

ID

ZDB-FIG-161129-1

Publication

Rochtus et al., 2016 - Methylome analysis for spina bifida shows SOX18 hypomethylation as a risk factor with evidence for a complex (epi)genetic interplay to affect neural tube development.

Other Figures

Fig. 4

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Fig. 4

Phenotype analysis of gene overexpression in zebrafish embryos. Pax2a staining after microinjection of abat mRNA (a) and sox18 mRNA (b). Wild-type (WT) zebrafish show expression in the hindbrain, hindbrain-midbrain boundary, neural tube, mesoderm, optic stalk, otic vesicle, and pronephric duct. Spinal cord malformation is indicated with an arrow. c Phenotype analysis after pax2a staining at 24 hpf resulted in respectively 50 and 74 % embryos with an affected phenotype after abat and sox18 overexpression. Folic acid supplementation after gene overexpression did not significantly influence the phenotype. ***P value <0.001

Expression Data

Gene:	pax2a
Fish:	AB
Anatomical Terms:	hindbrain mesoderm midbrain hindbrain boundary neural tube optic stalk otic vesicle pronephric duct
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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