FIGURE

Fig. 1

ID

ZDB-FIG-161111-1

Publication

de Peralta et al., 2016 - Cnbp ameliorates Treacher Collins Syndrome craniofacial anomalies through a pathway that involves redox-responsive genes

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Fig. 1

Tcof1 knockdown in zebrafish recapitulates TCS features. (a) RT-qPCR of rRNA transcripts (by ETS and ITS quantification) in samples from control (STD) and TRA-MO-injected 256 cell stage and 24 hpf embryos. Bars represent the mean of relative abundance and S.E.M., n=3, *P<0.05, **P<0.01 (t-test). AU: arbitrary units. (b and c) Ventral views of a typical control (b; STD-MO-injected) and a representative TCS-like (c; TRA-MO-injected) 4 dpf larvae stained with Alcian Blue. Meckel area (MA), area of the inner triangle defined by the Meckel cartilage, PQ length: length of palatoquadrate+hyosymplectic cartilages, ceratohyal length (CL): length of ceratohyal cartilage, CD: distance between ceratohyal cartilages joint and lateral fins, cranial distance (Cr): distance between the most anterior Meckel and lateral fins

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO3-nolc1
Knockdown Reagent:	MO3-nolc1
Observed In:	cranial cartilage embryonic cranial skeleton morphogenesis
Stage:	Day 4

Phenotype Detail

Acknowledgments

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