FIGURE

Fig. 5

ID

ZDB-FIG-160706-45

Publication

Kawase et al., 2016 - EP300 Protects from Light-Induced Retinopathy in Zebrafish

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Fig. 5

Inhibition of EP300 reduces the photoreceptor cell outer segments in a zebrafish model of light-induced retinopathy. (A) Protocol for light-induced retinal damage in larval zebrafish, as described for Figure 4A. After light exposure, whole-mount immunohistochemical staining with anti-Zpr3 antibody was performed. (B) Representative images of anti-Zpr3 antibody staining of zebrafish exposed to normal or intense light. Scale bars, 100 µm. (C) Quantitative analysis of photoreceptor cell outer segments of zebrafish exposed to the conditions shown in (B). *p < 0.05. Data are the mean ± SEM of n = 24 zebrafish/group for light-/C646- and light-/C646+, n = 17 for light+/C646-, and n = 22 for light+/C646+.

Expression Data

Antibody:	zpr-3
Fish:	slc45a2^b4/b4
Conditions:	chemical treatment: C646 high light intensity chemical treatment: C646, high light intensity
Anatomical Terms:	retina retinal cone cell photoreceptor outer segment retinal rod cell photoreceptor outer segment
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	slc45a2^b4/b4
Conditions:	high light intensity chemical treatment: C646, high light intensity
Observed In:	retina retinal cone cell photoreceptor outer segment retinal rod cell photoreceptor outer segment
Stage:	Day 6

Phenotype Detail

Acknowledgments

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