FIGURE

Fig. 5

ID

ZDB-FIG-160609-5

Publication

Giacomotto et al., 2016 - Developmental suppression of schizophrenia-associated miR-137 alters sensorimotor function in zebrafish

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Fig. 5

miR-137 knockdown does not impair Rohon–Beard- (RB-), dorsal root ganglia- (DRG-), trigeminal- or Mauthner-(M-)neurons differentiation and seems to not modify their overall network. SEN:GFP transgenic animals were injected with 8–16 ng of MO-Control or MO137-02 to observe RB, M and DRG cells in vivo. No significant difference with regard to the number of cells was observed between the different conditions (Counting available in Supplementary Figure 7). No obvious difference was observed in terms of axonal network, but an in-depth analysis should be performed to conclude. Following anti-GFP immunostaining, 10 animals per conditions were analyzed at different time points using confocal microscopy and image analysis. Brightness of the original image was enhanced. GFP, green fluorescent protein; MO, morpholino.

Expression Data

Gene:	EGFP
Fish:	bi128Tg bi128Tg + MO2-dre-mir-137
Knockdown Reagent:	MO2-dre-mir-137
Anatomical Terms:	dorsal root ganglion Mauthner neuron Rohon-Beard neuron
Stage Range:	Prim-5 to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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