FIGURE

Fig. 6

ID

ZDB-FIG-160609-11

Publication

Khan et al., 2016 - FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1

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Fig. 6

dnajb1 morphants display significant apoptosis in the eye.

TUNEL staining of control embryo sections (a-f) and dnajb1 morphants (g-l) injected with the dnajb1a sbMO (5 ng). The dnajb1a morphants show significantly increased apoptotic nuclei throughout the eye compared with the control embryo, which was completely devoid of TUNEL-positive nuclei. The morphant lens extends out of the retina and is fused to the cornea with an increased number of nuclei as compared with the control (white arrows, h,k) and is characterized by the presence of apoptotic nuclei in the centre of the lens (white arrows, i,l), suggesting an abnormal lens development. Note: the control embryo section image was acquired at a higher exposure time compared with the morphant to produce a background.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-dnajb1a
Knockdown Reagent:	MO1-dnajb1a
Observed In:	eye apoptotic process lens nucleus lens development in camera-type eye lens fiber cell differentiation
Stage:	Day 4

Phenotype Detail

Acknowledgments

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