FIGURE

Fig. 3

ID

ZDB-FIG-160412-10

Publication

Grone et al., 2016 - Epilepsy, Behavioral Abnormalities, and Physiological Comorbidities in Syntaxin-Binding Protein 1 (STXBP1) Mutant Zebrafish

Other Figures

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Fig. 3

Morphology of stxbp1a^s3000 mutant zebrafish.(A) Heterozygous stxbp1a^s3000/+ mutant larvae (5 dpf) are morphologically indistinguishable from wild-type siblings. Homozygous stxbp1a^s3000/s3000 mutant larvae are immobile and fail to hatch out of the chorion. Scale bar = 500 µm. (B) Homozygous stxbp1a^s3000/s3000 mutant larvae (n = 10) removed from their chorions are not significantly different in length from their siblings (n = 30; p = 0.0592, two-tailed t-test). (C-D) At 5 dpf, the dorsal surface of homozygous stxbp1a^s3000/s3000 mutant larvae that were removed from their chorions at 2 dpf (D) show dispersed melanin and foreshortened craniofacial structure compared to siblings (C). Scale bar = 300 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	stxbp1a^s3000/s3000 (WIK) stxbp1a^s3000/+
Observed In:	embryonic cranial skeleton morphogenesis hatching head anterior region whole organism
Stage:	Day 5

Phenotype Detail

Acknowledgments

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