FIGURE

Fig. 4

ID

ZDB-FIG-160325-3

Publication

Yuan et al., 2015 - CCAAT/enhancer-binding protein α is required for hepatic outgrowth via the p53 pathway in zebrafish

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Fig. 4

Loss of cebpa leads to enhanced hepatic cell proliferation and subsequent increased apoptosis.

(A-H) Hepatic cell proliferation and apoptosis were determined by pH3 staining and TUNEL assay in 60 and 72 hpf embryos, respectively. The sections were counterstained with DAPI to label the nucleus. Dashed lines circle the boundary of the liver. White arrows indicate pH3 or TUNEL positive cells, respectively. In each case or at each time-point, more than 5 sections from at least three sibling control or cebpa mutant fish were examined. (I) intestine. (I,J) Quantification of hepatic cell proliferation and apoptosis, respectively. Data shown are the mean ± SD, n ≥ 3, *P < 0.05 by student’s t-test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cebpa^rj31/+
Observed In:	liver apoptotic process liver cell population proliferation
Stage Range:	Pec-fin to Protruding-mouth

Phenotype Detail

Acknowledgments

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