FIGURE

Fig. 4

ID

ZDB-FIG-160210-11

Publication

Guarienti et al., 2015 - Computational and functional analysis of biopharmaceutical drugs in zebrafish: erythropoietin as a test model

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Fig. 4

Negative control (Neg ctrl), Eprex^�, Binocrit^� or Retacrit^� injected in 48 hpf tg (kdrl:EGFP; gata1:ds-red) casper embryos and photographed after 4 h. (A) Double channel fluorescence: in green blood vessels, expressing kdrl:EGFP and in red circulating erythrocytes, expressing gata1:ds-red. Lateral views, anterior to the left, 11.5X magnification; (B) single red-channel fluorescence shows circulating erythrocytes, expressing gata1:ds-red. Lateral views, anterior to the left, 4X magnification. Quantification of (C) red fluorescence signal and (D) green fluorescence signal, measured with ImageJ 1.45 s image analysis software on a mean of 25 embryos for each experimental point. Asterisk indicates statistically significant increase of the positive area (p < 0.05), data are the mean � S.D. of 3 independent experiments. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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