ZFIN ID: ZDB-FIG-151014-40
Grati et al., 2015 - A missense mutation in DCDC2 causes human recessive deafness DFNB66, likely by interfering with sensory hair cell and supporting cell cilia length regulation. Human molecular genetics   24(9):2482-91 Full text @ Hum. Mol. Genet.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Knockdown Reagent:
Anatomical Terms:
Stage: Protruding-mouth
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage: Protruding-mouth

Fig. 4 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
dcdc2b AB standard conditions Protruding-mouth otic vesicle ISH
GFP s356tTg control Protruding-mouth neuromast hair cell IFL
s356tTg + MO3-dcdc2b control Protruding-mouth neuromast hair cell IFL
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
AB + MO3-dcdc2b standard conditions Protruding-mouth hair cell decreased functionality, abnormal
Protruding-mouth sensory perception of sound disrupted, abnormal
s356tTg + MO3-dcdc2b standard conditions Protruding-mouth neuromast hair cell decreased amount, abnormal
Protruding-mouth neuromast hair cell degenerate, abnormal
Protruding-mouth neuromast hair cell kinocilium morphology, abnormal
Protruding-mouth neuromast hair cell stereocilium bundle morphology, abnormal
Protruding-mouth saccule hair cell decreased amount, abnormal
Protruding-mouth semicircular canal hair cell decreased amount, abnormal
Full text @ Hum. Mol. Genet.