FIGURE

Fig. 7

ID

ZDB-FIG-150708-25

Publication

Harrison et al., 2015 - Chemokine-guided angiogenesis directs coronary vasculature formation in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 7

cxcr4a Mutant Hearts Fail to Regenerate following Resection of the Ventricle Apex

Zebrafish with functional Cxcr4a-Cxcl12b signaling and normal coronary vessel development completely regenerate resected ventricle tissue after 60 days (A, dashed line represents amputation plane, and A′). Adult cxcr4a mutants with disrupted coronary vessel development fail to regenerate the resected tissue resulting in the deposition and persistence of collagen (blue) and fibrin (red) (B, B′, E, and G). Quantification of scar formation at 60 dpa (C). cxcr4 mutant zebrafish have significantly more collagen deposition and scar formation compared to the siblings (p < 0.0001, chi-square). Scar formation is observed by 30 dpa (D and E) and persists beyond 120 dpa (F and G) with no apparent effect on survival. Scale bars represent 50 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Cell, 33, Harrison, M.R., Bussmann, J., Huang, Y., Zhao, L., Osorio, A., Burns, C.G., Burns, C.E., Sucov, H.M., Siekmann, A.F., Lien, C.L., Chemokine-guided angiogenesis directs coronary vasculature formation in zebrafish, 442-54, Copyright (2015) with permission from Elsevier. Full text @ Dev. Cell