FIGURE

Fig. 5

ID

ZDB-FIG-150616-37

Publication

Torraca et al., 2015 - The CXCR3/CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection

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Fig. 5

Macrophage chemoattraction by locally injected recombinant chemokines in cxcr3.2 mutant and wild-type siblings. Recombinant proteins or buffer (mock) were injected into the hindbrain ventricle at 30 hpf and macrophages accumulating in 3 hours within the hindbrain limits were counted as Lp-stained cells. Data were accumulated from three independent experiments. (A) Cxcl11aa (1.2 mg/ml). Sample size (n): 51, 60, 55, 60. (B) Cxcl11ae (0.5 mg/ml). Sample size (n): 54, 51, 42, 56. (C) Cxcl11af (0.5 mg/ml). Sample size (n): 47, 68, 39, 58. Error bars: median and interquartile range. Note that macrophage chemoattraction mediated by Cxcl11aa and Cxcl11af is abolished by cxcr3.2 mutation, whereas the chemoattraction mediated by Cxcl11ae is independent of cxcr3.2. ns, non-significant; **P<0.01; ***P<0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cxcr3.2^{hu6044/hu6044}
Condition:	chemical treatment: chemical substance
Observed In:	chemoattractant activity macrophage chemotaxis neutrophil chemotaxis
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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