FIGURE

Fig. 5

ID

ZDB-FIG-150527-20

Publication

Olena et al., 2015 - miR-216a regulates snx5, a novel notch signaling pathway component, during zebrafish retinal development

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Fig. 5

miR-216a and snx5 regulate Müller glia cell numbers. Tg(gfap:GFP) transgenic zebrafish were injected as indicated, grown to 65 hpf, and GFP+ cell numbers were counted. Compared to DICs, injection of miR-216a^MOs or snx5 caused a significant increase in GFP+ cells (p<0.05). Injections with miR-216a or snx5^MOs caused a significant decrease in GFP+ cells (p<0.05). Partial rescue of GFP+ cell counts was observed in embryos co-injected with combinations of either snx5 and miR-216a, or snx5^MOs and miR-216a^MOs. Error bars=SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mi2001Tg + MO1-dre-mir-216a + MO2-dre-mir-216a mi2001Tg + MO1-snx5 + MO2-snx5 mi2001Tg + MO1-dre-mir-216a + MO1-snx5 + MO2-dre-mir-216a + MO2-snx5
Knockdown Reagents:	MO1-dre-mir-216a MO1-snx5 MO2-dre-mir-216a MO2-snx5
Observed In:	Muller cell
Stage:	Pec-fin

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 400(1), Olena, A.F., Rao, M.B., Thatcher, E.J., Wu, S.Y., Patton, J.G., miR-216a regulates snx5, a novel notch signaling pathway component, during zebrafish retinal development, 72-81, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.