FIGURE

Fig. 6

ID
ZDB-FIG-150520-16
Publication
Ju et al., 2015 - Oncogenic KRAS promotes malignant brain tumors in zebrafish
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Fig. 6

Oncogenic KRAS expression in CNS increases mitotic activity in the spinal cords. (A, B) 120hpf larvae from an inducible Tg(gfap:rtTA:mCherryKRASG12V) line showed heart edema (arrow), body curvature, and hyperpigmentation of the trunk. At 72hpf, wild-type larvae showed prominent expression of GFAP in the spinal cord (C), and few cells were undergoing mitosis (D). Expression of oncogenic KRAS disrupted the normal GFAP expression pattern in the spinal cord (E), and significantly increased the number of cells undergoing mitosis (F, arrows). SC, spinal cord. Scale bars, 250 µm.
Expression Data
Gene:
Antibodies:
Fish:
Condition:
Anatomical Terms:
Stage Range: Protruding-mouth to Day 5

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Condition:
Observed In: (all 6)
Stage Range: Protruding-mouth to Day 5

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol. Cancer
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