FIGURE

Fig. 5

ID
ZDB-FIG-150520-15
Publication
Ju et al., 2015 - Oncogenic KRAS promotes malignant brain tumors in zebrafish
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Fig. 5

MEK inhibitor U0126 suppresses proliferative effect of oncogenic KRAS in skin epithelial cells. (A) Graphic representation of driver and effector DNA constructs for generation of Dox-inducible stable transgenic lines. (B, C) In an inducible Tg(krt5:rtTA:mCherryKRASG12V) transgenic line, 48hpf larvae treated with 10 µg/ml Dox showed skin hyperplasia, most noticeably under the yolk sac (arrows). 50 µM U0126 treatment completely eliminated the skin hyperplasia (arrow heads). Scale bar, 250 µm.
Expression Data
Gene:
Fish:
Conditions:
Anatomical Term:
Stage: Long-pec

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Conditions:
Observed In:
Stage: Long-pec

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol. Cancer
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