FIGURE

Fig. 4

ID

ZDB-FIG-150507-14

Publication

Gramage et al., 2015 - Midkine-a Protein Localization in the Developing and Adult Retina of the Zebrafish and Its Function During Photoreceptor Regeneration

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Fig. 4

Mdka protein localization following photoreceptor ablation.

In unlesioned retinas, Mdka immunostaining is localized to the horizontal cells and endfeet of glutamine synthetase (GS)-positive Müller glia (row A). At 4 dpl, Mdka antibodies label the radial processes of Müller glia (row B, arrows). Note the increased Mdka immunostaining in the endfeet of the Müller glia in lesioned retinas (cf. rows A and B). Also at 4 dpl, Mdka immunostaining is localized to each of the EdU-positive nuclei in both the INL and ONL (row C, arrowheads). ONL: outer nuclear layer; INL: inner nuclear layer; dpl: days post lesion. Scale bars = 25 µm.

Expression Data

Gene:	mdka
Antibodies:	Ab1-glul Ab1-mdka
Fish:	AB
Condition:	light ablation: photoreceptor cell
Anatomical Terms:	horizontal cell Muller cell glial cell projection Muller cell glial limiting end-foot
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Condition:	light ablation: photoreceptor cell
Observed In:	Muller cell retinal neural layer sensory epithelium regeneration
Stage:	Adult

Phenotype Detail

Acknowledgments

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