FIGURE

Fig. 3

ID

ZDB-FIG-150506-24

Publication

Sasore et al., 2014 - Deciphering Combinations of PI3K/AKT/mTOR Pathway Drugs Augmenting Anti-Angiogenic Efficacy In Vivo

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

PI3K/Akt/mTOR inhibitors inhibit developmental angiogenesis of the intersegmental vasculature.

Representative images demonstrating anti-angiogenic effects of PI3K/Akt/mTOR inhibitors on ISV development. In 0.1% DMSO-treated control larvae ~25 ISVs pairs develop (A) and high magnification (B). 5 µM NVP-BEZ235 + PI-103 (C), 5 µM LY294002 + NVP-BEZ235 (D) and 10 µM NVP-BEZ235 (E) exhibited significant anti-angiogenic effects compared to individual drugs at 5 µM (F-H). White arrows indicate the ISVs sprouting from the dorsal aorta (DA) to the dorsal longitudinal anastomic vessel (DLAV). Scale bar in A is 500 µm and in B is 100 µm (B). n = 25-30.

Expression Data

Gene:	EGFP
Fish:	y1Tg
Condition:	chemical treatment: pharmaceutical
Anatomical Terms:	dorsal aorta intersegmental vessel vasculature
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	y1Tg
Condition:	chemical treatment: pharmaceutical
Observed In:	intersegmental vessel sprouting angiogenesis
Stage:	Prim-5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One