FIGURE

Fig. 6

ID
ZDB-FIG-150506-18
Publication
Yakkundi et al., 2015 - FKBPL Is a Critical Antiangiogenic Regulator of Developmental and Pathological Angiogenesis
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Fig. 6

FK506-binding protein like (FKBPL) regulates vessel development in zebrafish embryos (A). Vessel quantification of 72 hpf embryos microinjected with AD-01 (1.3 pmol), demonstrating the inhibition of the intersegmental vessel (ISV) development. B and C, Graphs demonstrating a significant reduction in the number of embryos with normal vessels after injection of the Splice MO (B) and UTR MO (C), and significant phenotype rescue after coinjection of full length, N or C terminal hFKBPL mRNA in a Cd44-dependent manner. Embryos showing intact ISV formation at the indicated time points are defined as normal embryos in the quantification. Data points are meanĀ±SEM. ne3. *P<0.05, **P<0.01, ***P<0.001 (1-way ANOVA, Tukey multiple comparison post tests). D, Photomicrographs of 48 hpf embryos injected with control MO/zfkbpl MO (UTR) showing the disrupted vasculature; arrows indicate the trunk and tail vessels, and this was rescued by expression of full length hFKBPL mRNA. All the images are lateral views, anterior toward left.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Knockdown Reagents:
Observed In:
Stage: Long-pec

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Arterioscler. Thromb. Vasc. Biol.